Genesis 3:15

And I will put enmity between you and the woman, and between your seed and her seed; he shall bruise your head, and you shall bruise his heel.
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Ambrose of Milan

AD 397
God judged that evil was to be held in check for a time rather than to be destroyed, so that he says to the serpent, “I will put enmity between you and the woman, and between your seed and the seed of the woman. She shall watch for your head and you for her heel.” Where enmities remain, there remains discord and the desire to do harm. Where there is the desire to do harm, there evil is established. Therefore there is discord between the serpent and the woman. Evil is at the base of discord; thus evil has not been taken away. Indeed, it has been reserved for the serpent, that he might watch for the woman’s heel and the heel of her seed, so as to do harm and infuse his poison. Therefore let us not walk in earthly things, and the serpent will not be able to harm us. Let us put on sandals of the gospel that shut out the serpent’s poison and blunt his bites that we may be provided with covering on our feet by the gospel.

Augustine of Hippo

AD 430
Enmities are not set between the serpent and the man but between the serpent and the woman. This is surely not because he fails to deceive and tempt men, is it? On the contrary, it is clear that he does deceive them. Or is it because he did not deceive Adam but his woman? But is the serpent then not the enemy of the man to whom that deception came through his woman, especially since “I will place enmity between you and the woman” is stated in the future? If the reason is that he did not thereafter deceive Adam, it is also true that he did not thereafter deceive Eve. Hence, why does Scripture put it this way? To show clearly that we cannot be tempted by the devil except through that animal part, which reveals, so to speak, the image or exemplification of the woman in the one whole man. .

Ephrem The Syrian

AD 373
"You are more cursed than all cattle because you deceived those who have authority over all cattle; and instead of being more astute than all other animals you shall be more cursed than all other animals, and you shall go about on your belly because you brought pangs upon womankind. And you shall eat dust all the days of your life [ Gen. 3:14 ] because you deprived Adam and Eve of the food of the Tree of Life. And I will place enmity between you and the woman, and between your seed and her seed [ Gen. 3:15 ] because by your fraudulent show of love you deceived and subjected both her and her children to death. He then indicates the nature of the enmity which was placed between the serpent and the woman, between its seed and hers, saying, "It shall tread upon your head--which wanted to escape from subjugation to her seed--and you will strike it, not in its organ of hearing, but in its heel. " [ Gen. 3:15 ]

George Leo Haydock

AD 1849
She shall crush. Ipsa, the woman: so divers of the fathers read this place, conformably to the Latin: others read it ipsum, viz. the seed. The sense is the same: for it is by her seed, Jesus Christ, that the woman crushes the serpent's head. (Challoner) The Hebrew text, as Bellarmine observes, is ambiguous: He mentions one copy which had ipsa instead of ipsum; and so it is even printed in the Hebrew interlineary edition, 1572, by Plantin, under the inspection of Boderianus. Whether the Jewish editions ought to have more weight with Christians, or whether all the other manuscripts conspire against this reading, let others inquire. The fathers who have cited the old Italic version, taken from the Septuagint agree with the Vulgate, which is followed by almost all the Latins; and hence we may argue with probability, that the Septuagint and the Hebrew formerly acknowledged ipsa, which now moves the indignation of Protestants so much, as if we intended by it to give any divine honour to the...

Irenaeus of Lyons

AD 202
Christ completely renewed all things, both taking up the battle against our enemy and crushing him who at the beginning had led us captive in Adam, trampling on his head, as you find in Genesis that God said to the serpent, “I will put enmity between you and the woman, and between your seed and the seed of the woman. He will be on the watch for your head, and you will be on the watch for his heel.” From then on it was proclaimed that he who was to be born of a virgin, after the likeness of Adam, would be on the watch for the serpent’s head. This is the seed of which the apostle says in the letter to the Galatians, “The law of works was established until the seed should come to whom the promise was made.” He shows this still more clearly in the same epistle when he says, “But when the fullness of time was come, God sent his Son, made of a woman.” The enemy would not have been justly conquered unless it had been a man made of woman who conquered him. For it was by a woman that he had pow...

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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