And I will put enmity between you and the woman, and between your seed and her seed; he shall bruise your head, and you shall bruise his heel.
All Commentaries on Genesis 3:15 Go To Genesis 3
Ephrem The Syrian
AD 373
"You are more cursed than all cattle because you deceived those who have authority over all cattle; and instead of being more astute than all other animals you shall be more cursed than all other animals, and you shall go about on your belly because you brought pangs upon womankind. And you shall eat dust all the days of your life [ Gen. 3:14 ] because you deprived Adam and Eve of the food of the Tree of Life. And I will place enmity between you and the woman, and between your seed and her seed [ Gen. 3:15 ] because by your fraudulent show of love you deceived and subjected both her and her children to death.
He then indicates the nature of the enmity which was placed between the serpent and the woman, between its seed and hers, saying, "It shall tread upon your head--which wanted to escape from subjugation to her seed--and you will strike it, not in its organ of hearing, but in its heel. " [ Gen. 3:15 ]