Isaiah 48:16

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Come near unto me, hear this; I have not spoken in secret from the beginning; from the time that it was, there am I: and now the Lord GOD, and his Spirit, has sent me.

Verse 15 Read Chapter 48 Verse 17

Augustine of Hippo

AD 430

Furthermore, he could not be sent by the Father without the Holy Spirit. On principle, when the Father sent him, that is made him of woman, he cannot be supposed to have done it without the Spirit.… There is even a prophecy of Isaiah in which Christ himself is understood as saying about his future coming, “And now the Lord and his Spirit has sent me.” - "On the Trinity 2.2.8"

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Augustine of Hippo

AD 430

Now it is Jesus Christ who is speaking here as the “Lord God”; yet this would not have been obvious if he had not added the final words, “And now the Lord God has sent me and his Spirit.” These words were spoken by Christ in his “form” as a “servant.” He used a verb in the past tense to indicate a future event. - "City of God 20.30"

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Cyril of Alexandria

AD 444

Those who look toward the Savior do not attribute grace for salvation to other gods but to him. For it is said about him that he was moved by love, that is, he was most loving and kind to them in that he was prepared to go all the way to the very end, to the uprooting of the seed of the Chaldeans, that is, those who fought against them and perpetrated all sorts of inhuman acts.… I am spurred by love for you that I will do what is your pleasure in the land of the Babylonians, so that the seed of the Chaldeans will be removed. For [Isaiah] speaks here about Cyrus. - "Commentary on Isaiah 4.3.48.15–16"

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Ephrem The Syrian

AD 373

“From the time this plague came to be” in all my people, “I have been there.” In order that the words he had spoken may not be despised by the sorcerers, the text shows that they do not belong to the prophet as such, but to the Lord and his Spirit, who sent the prophet to preach to them. Indeed, the prophet clearly said as if from the person of the Lord, “I am in all my people, and my right hand extends to the heavens.” - "Commentary on Isaiah 48.16"

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George Leo Haydock

AD 1849

Spirit. The Fathers here find the three Persons of the blessed Trinity specified. Isaias was not from the beginning, though the text may also speak of him (Calmet) as he spoke long before the event, by divine inspiration. (Chaldean) (St. Jerome)

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Jerome

AD 420

When all things were made by the Father, he [the Son] was there with him, in whom the Son rejoiced when he said, I am he who always was with the Father and in the Father and never was without the Father, and who now speaks, and due to the weakness of the flesh I assumed, I say that “the Lord has sent me and his Spirit.” In this short verse we are shown the mystery of the Trinity. - "Commentary on Isaiah 13.16"

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Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20