Therefore I have profaned the princes of the sanctuary, and have given Jacob to the curse, and Israel to reproaches.
Read Chapter 43
Ephrem The Syrian
AD 373
“Your princes profaned the sanctuary.” Those who were from the house of Manasseh profaned the sanctuary with the four-faced idol, which they placed inside the sanctuary. Because of those crimes, and in particular because of Manasseh’s crime, “I have given Jacob to the curse, and Israel to reviling.” - "Commentary on Isaiah 43.28"
Profaned, or declared such, (Haydock) Nadab, (Leviticus x. 1.; Calmet) or Moses and Aaron. (Menochius)
Septuagint, "and the princes defiled my holy things. "(Haydock)
Slaughter. Hebrew, "anathema. "Yet I will re-establish all. (Calmet)