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Isaiah 35:3

Strengthen you the weak hands, and make firm the feeble knees.
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Ambrose of Milan

AD 397
Then let us flee the wickedness of this world, in which “the very days are evil,” and flee it relentlessly. On that account Isaiah cries out, “Be strong, you hands which are feeble and you knees which are without strength.” This means: Be strong, you knees, not of the body but of the soul, so that the footstep of the spirit can rise up straightway to the heights of heaven. Thus conduct will be more stable, life more mature, grace more abundant and discretion more guarded. - "Flight from the World 7.37"

Ambrose of Milan

AD 397
Therefore the traders came from Gilead, that is, from their possessions of or dwelling in the law, and brought their wares to the church, so that that balm might heal the sins of the nations. Of them it is said, “Be strong, you hands that are feeble and you knees that are without strength.” The balm is unspoiled faith. Such a faith Peter exhibited when he said to the lame man, “In the name of Jesus Christ of Nazareth, arise and walk.” And he arose and walked, as was right. Such a faith Peter had when he said to the paralytic, “Aeneas, the Lord Jesus heals you; get up and make your bed.” And he got up and made his bed. Such a faith he had when he said to the dead woman, “Arise in the name of our Lord Jesus Christ.” And the departed woman arose. With the mortar made from this cement those stones are fastened together from which God is able to raise up children to Abraham. - "On Joseph 3.17"

Chromatius of Aquileia

AD 407
The grace of this time in which John was exhorting sinners to repentance and baptizing those who confessed their sins in the desert, Isaiah previously witnessed when he said, “The desert will rejoice and blossom like the lily. The desert of the Jordan will bloom and exult. Strengthen the hands of the abandoned and bolster their weak knees. You who are lowly of soul, be encouraged and do not fear.” - "Tractate on Matthew 10.1"

Eusebius of Caesarea

AD 339
Now we have this prophecy fulfilled in the Gospels, partly, when they brought to our Lord and Savior a paralytic lying on a bed, who he made whole with a word; and partly, when many that were blind and possessed with demons, yes, laboring under various diseases and weaknesses, were released from their sufferings by his saving power. Nor should we forget how even now throughout the whole world multitudes bound by all forms of evil, full of ignorance of Almighty God in their souls, are healed and cured miraculously and beyond all argument by the medicine of his teaching. Except that now we call him God as we should, as one who can work thus, as I have already shown in the evidence of his divinity. Yes, surely it is right now to acknowledge him to be God, since he has given proof of power divine and truly inspired. For it was specifically God’s work to give strength to the paralyzed, to give life to the dead, to supply health to the sick, to open the eyes of the blind, to restore the lame...

George Leo Haydock

AD 1849
Knees. Ye prophets, comfort the people with these promises. (Calmet) The apostles taught the Gentiles to do good. (Menochius)

Tertullian of Carthage

AD 220
The sick of the palsy is healed, and that in public, in the sight of the people. For, says Isaiah, “they shall see the glory of the Lord and the excellence of our God.” What glory, and what excellence? “Be strong, you weak hands and feeble knees” refers to the palsy. “Be strong; fear not.” “Be strong” is not vainly repeated, nor is “fear not” vainly added; because with the renewal of the limbs there was to be, according to the promise, a restoration also of bodily energies: “Arise, and take up your couch”; and likewise moral courage not to be afraid of those who should say, “Who can forgive sins, but God alone?” - "Against Marcion 4.10.1"

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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