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Genesis 46:27

And the sons of Joseph, who were born to him in Egypt, were two souls: all the souls of the house of Jacob, who came into Egypt, were three score and ten.
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Ambrose of Milan

AD 397
Therefore seventyfive souls go down into Egypt, just as it is written, and this in the mystical sense is the number of forgiveness. For after such great hardness, after such great sins, they would be considered unworthy unless there were granted them the forgiveness of sins. Judah—that is, the confession of sin—goes to meet Joseph. The people of the Jews that is to come sends him ahead as a forerunner of itself. So also the true Joseph, that is, “the witness and interpreter of the Godhead,” comes to meet those who before were in the possession of unbelief, because now their confession precedes them. For Christ is the interpreter of the Godhead, because “no one has at any time seen God, except the onlybegotten Son, who is in the bosom of the Father; he has revealed him.” It is he who in the last times will receive the people of the Jews, by then in an advanced age and grown weary, and do so, not according to its merits but according to the election of his grace; and he will put his hand...

John Chrysostom

AD 407
Why did sacred Scripture indicate the number to us precisely? So that we might be in a position to know how God’s prediction took effect that said, “I will make you into a great nation there.” You see, from those seventyfive persons the people of Israel grew into six hundred thousand. You notice how it was not idly or to no purpose that it taught us the number of those that went down to Egypt, but for us to know from how few that great number came and not to lose confidence in God’s promises. I mean, when you consider that after the death of Jacob and Joseph the king of the Egyptians went to such lengths to reduce their numbers and prevent them from growing, be amazed and overcome at God’s providence and the fact that his wishes can never fail, no matter how many people try their utmost.

Quodvultdeus

AD 450
Therefore Jacob went down to Egypt together with seventyfive people, and his son Joseph came to meet him. After seeing him Jacob said, “I see you, son, now I can die willingly.” When Simeon, that venerable old man, called a father because of his age and not because he could father children, saw Christ because of whom he was still kept in this world as in Egypt, even though he was extremely old, said, “Master, now you are dismissing your servant in peace, according to your word; for my eyes have seen your salvation.” David’s Psalm , which coincides with the number of the people, proclaims, “God is known in Judea, and his name is great in Israel.” Since Israel means “he who sees God,” it is necessary that every person enlightened by grace, Jew or Greek, is freed from the slavery of Egypt, even though Pharaoh, that is, the devil, oppresses him with a heavy yoke. .

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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