And Isaac spoke unto Abraham his father, and said, My father: and he said, Here am I, my son. And he said, Behold the fire and the wood: but where is the lamb for a burnt offering?
Read Chapter 22
Ambrose of Milan
AD 397
Therefore he brought his beloved son to be sacrificed, and him whom he had begotten so late he offered without delay. Nor was he held back by being addressed as father, when his son called him “father” and he answered “my son.” On His Brother, Satyrus
In two things then was Abraham victorious: that he killed his son although he did not kill him and that he believed that after Isaac died he would be raised up again and would go back down with him. For Abraham was firmly convinced that he who said to him, “through Isaac shall your descendants be named,” was not lying.
Holocaust. These were probably the only sacrifices yet in use. (Calmet)
The conversation of Isaac could not fail to pierce the heart of his father. (Menochius)