Genesis 2:24

Therefore shall a man leave his father and his mother, and shall cleave unto his wife: and they shall be one flesh.
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Ambrose of Milan

AD 397
If the union of Adam and Eve is a great mystery in Christ and in the church, it is certain that as Eve was bone of the bones of her husband and flesh of his flesh, we also are members of Christ’s body, bones of his bones and flesh of his flesh.

Aphrahat the Persian Sage

AD 345
From the law we heard: “Therefore a man leaves his father and his mother and cleaves to his wife, and they will become one flesh.” This is a great and sublime prophecy. Who actually leaves his father and mother when he takes a wife? This is the meaning of the words: man in his original condition loved and worshiped God, his father, and the Holy Spirit, his mother. He did not have any other love. In order to take a wife, man leaves his mother and father, those whom I mentioned above. His mind is thereby diverted by this world. His soul and mind are driven away from God and drawn into this world that he adores and loves “as a man loves the wife of his youth.” The love for this wife is different from the love for the father and the mother. Scripture adds, “They will become one flesh.” It is true that as some men make one flesh and soul with their wife, and their mind and thoughts are driven away from their father and mother, so those who never take a wife and stay alone may have a single ...

Augustine of Hippo

AD 430
Scripture said, “A man will leave father and mother, and he will cling to his wife, and they will be two in one flesh.” This is what generally happens in the human race. There is no other way to view its plain, historical sense. But more so, this is all prophecy, and the apostle reminds us of this when he says, “For this reason a man will leave his father and mother and he will cling to his wife, and they will be two in one flesh. This is a great mystery; I mean in Christ and in the church.” .

Ephrem The Syrian

AD 373
He said "a man shall leave his father and his mother and attach himself to his wife " [ Gen. 2:24 ] so that they might be united and the two of them become one, without division, as they were originally.

Ephrem The Syrian

AD 373
Then Adam said, “Let the man leave his father and his mother and cling to his wife so that they might be joined and the two might become one” without division as they were from the beginning. .

George Leo Haydock

AD 1849
One flesh, connected by the closest ties of union, producing children, the blood of both. St. Paul, Ephesians v. 23, discloses to us the mystery of Christ's union with his church for ever, prefigured by this indissoluble marriage of our first parents. (Calmet)

John Chrysostom

AD 407
Where, tell me, did these things come from for him to utter? From what source did he gain knowledge of future events and the fact that the race of human beings should grow into a vast number? Whence, after all, did he come to know that there would be intercourse between man and woman? I mean, the consummation of that intercourse occurred after the fall; up till that time they were living like angels in paradise and so were not burning with desire, not assaulted by other passions, not subject to the needs of nature; on the contrary, they were created incorruptible and immortal, and on that account at any rate they had no need to wear clothes…. So from what source, tell me, did these things come for him to utter? Surely it’s obvious that before his disobedience he had a share in prophetic grace and saw everything through the eyes of the Spirit. –.

Tertullian of Carthage

AD 220
There were more ribs in Adam, and hands that knew no weariness in God; but not more wives in the eye of God. And accordingly the man of God, Adam, and the woman of God, Eve, discharging mutually (the duties of) one marriage, sanctioned for mankind a type by (the considerations of) the authoritative precedent of their origin and the primal will of God. Finally, "there shall be," said He, "two in one flesh," not three nor four. On any other hypothesis, there would no longer be "one flesh," nor "two (joined) into one flesh." These will be so, if the conjunction and the growing together in unity take place once for all. If, however, (it take place) a second time, or oftener, immediately (the flesh) ceases to be "one," and there will not be "two (joined) into one flesh," but plainly one rib (divided) into more. But when the apostle interprets, "The two shall be (joined) into one flesh" of the Church and Christ, according to the spiritual nuptials of the Church and Christ (for Christ is one,...

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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