And through his cunning also he shall cause deceit to prosper under his hand; and he shall magnify himself in his heart, and without warning shall destroy many: he shall also stand up against the Prince of princes; but he shall be broken, by no human hand.
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Aquinas Study Bible
In a more general way it can point to the time of the Antichrist on account of his great wickedness. But more specifically this is the time of Antiochus Epiphanes, who was a figure of the Antichrist, who pursued the worship of God. for the time has its end: that is when those things will be completed. (Nicholas of Lyra) ...
Hand of man. He confessed that he was justly punished, 1 Machabees vi. 10. Greek, "He shall raise himself by the ruin of many, (Theod. and some manuscripts add, and shall rise up against the prince of princes) and he shall break them like eggs with his hand."