Then said I, Lord, how long? And he answered,
Until the cities are wasted without inhabitant, and the houses without man, and the land is utterly desolate,
All Commentaries on Isaiah 6:11 Go To Isaiah 6
Eusebius of Caesarea
AD 339
See here that the rest of the earth is desolate, and those who remain on the earth alone are said to multiply. These must be the disciples of the Savior, going forth from the Hebrews to all people. Like a seed left behind they have brought forth much fruit, which are the churches of the Gentiles in every dwelling place. In addition, when he says that only those who remain from the falling away of the Jews will multiply, he also says that the Jews themselves are desolate. For he says of them, “Their land shall be left desolate.” And this was said to them before by the same prophet, saying, “Your land is completely desolate, your cities burned with fire, before you strangers will devour your country.”
When was this fulfilled other than in the time of our Savior? Before they dared to do evil things to him, their land was not desolate, their cities not burned with fire, and strangers did not devour their country. Our Savior and Lord predicted what was to happen to them through that prophetic announcement, saying, “Your house is left to you desolate.” It was not long from the prediction of that moment that the Romans laid siege to them and brought them to desolation.
The prophetic word gives the reason for the desolation by showing the cause of their fall, making the understanding of it clear. When they heard our Savior teaching among them but would not listen with the ear of the mind and did not understand who he was, seeing him with their eyes and not with the eyes of their spirit, “they hardened their heart, closed the eyes of their mind, and made their ears heavy.” As the prophecy says, their cities would become desolate such that no one would live in them because of this. In addition, their land would become desolate, and only a few would remain, being kept like fruitful seed who would proceed to all people and multiply on the earth.