And one cried unto another, and said, Holy, holy, holy, is the LORD of hosts: the whole earth is full of his glory.
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Cyril of Alexandria
AD 444
In announcing that the whole earth is full of his glory, the seraphim are predicting the mystery of the economy that will be brought to pass through Christ. Prior to the Word’s becoming flesh the world was ruled by the devil, the evil one, the serpent, the apostate. The creature, rather than the Creator, was worshiped. But when the only-begotten Word of God became human, the entire earth was filled with his glory.