And I will lay it waste: it shall not be pruned, nor dug; but there shall come up briers and thorns: I will also command the clouds that they rain no rain upon it.
All Commentaries on Isaiah 5:6 Go To Isaiah 5
Jerome
AD 420
It is obvious enough that the prophet is referring to the apostles and to the saints; that they are not to rain his rain upon the Jews but upon the Gentiles.