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1 Samuel 5:6

But the hand of the LORD was heavy upon them of Ashdod, and he destroyed them, and struck them with tumors, even Ashdod and the territory thereof.
All Commentaries on 1 Samuel 5:6 Go To 1 Samuel 5

Gregory The Dialogist

AD 604
And this explains how they died. It is said that each one died when he went out to purge his bowels and was bitten in the inner part of his buttocks by mice. Now this wound is shown here in a literal fashion, but it is united with an allegorical exposition. For in its literal meaning, it refers to the illness caused by the hand of the Lord and the bites of the mice, which led to the outcome of death. It is said that the hand of the Lord weighed heavily upon the inhabitants of Ashdod because they were being killed by the mouse bites. In giving this passage its spiritual meaning, however, we recognize two kinds of deaths: the first kind of death is that by which sinners die to righteousness when they sin; the second kind of death is that by which the righteous deliver themselves from the sins in which they had lived and repent of them. The first kind of death enters into human hearts whenever the devil persuades someone to sin. The second kind of death is effected by the virtue of almighty God. Therefore, we must give attention to both kinds of death in this place as they are alluded to spiritually. The one type of death, by which sinners arise when they repent of their sins is alluded to by the words “The hand of the Lord was heavy upon the inhabitants of Ashdod.” But that type of death by which the Gentiles offered themselves as slaves to impurity and sin is alluded to when the people of Ashdod were bitten by the mice and died. A mouse, after all, is an unclean animal and could not be eaten according to the law. Therefore, what else could the mice refer to except to demons? And what else is being bitten by mice except being wounded by the penalty for sin? But they were bitten by the mice when they went out to purge their bowels. Now what does it mean to purge one’s bowels other than to reveal the stench of a wretched reputation by one’s obedience to sin? Thus, whoever went out to purge his bowels died by the bites of the mice, for by his sinning in plain sight of others he showed them an example of depravity, and he himself was also detained for eternal death by his dire obligations to the demons.
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Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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