And Cain went out from the presence of the LORD, and dwelt in the land of Nod, on the east of Eden.
All Commentaries on Genesis 4:16 Go To Genesis 4
Ephrem The Syrian
AD 373
After Cain received the punishment and the sign had been added to it … Moses said that “Cain went away from the presence of the Lord and dwelt in the land of Nod, east of Eden.” Cain, therefore, separated himself from his parents and his kin because he saw that they would not intermarry with him. .