Romans 16:5

Likewise greet the church that is in their house. Greet my well beloved Epaenetus, who is the firstfruits of Achaia unto Christ.
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AD 400
Paul mentions Epaenetus’s claim to fame, in order to show that important people believe and turn to the faith and in order to invite the leaders of the Romans to accept Christ, and if they have already done so, to become humble. Commentary on Paul’s Epistles.

George Leo Haydock

AD 1849
This means the assembly of Christians, who probably resorted to the house of Prisca and Aquila, as to a place of retreat, and there held their religious assemblies. Or it may mean their family only, which was as regular and holy as an assembly of saints. The apostle, in another place, salutes the Church in the house of Nympha, and writing to Philemon, salutes the Church in his house. (1 Corinthians xvi. 19.) ...

John Chrysostom

AD 407
Priscilla was noble enough to make their house a church, both by converting everyone in it and by opening it to strangers. Paul did not normally call houses churches, except when there was much godliness in them…. For even married people may become worthy of esteem and noble. These were married and became very honorable, even though their profession was that of tentmaker, which is far from honorable in itself. Note how Paul calls Epaenetus “beloved,” which is high praise indeed. For Paul did not use a word like this to show favoritism; rather, it was the result of calm, cool reflection. Moreover, he was the first convert in Achaea, either in time or in quality…. Given that it was likely that all these people were of humble birth, Paul shows what true nobility is and honors them accordingly. ...

Knowing this first, that no prophecy of the scripture is of any private interpretation. - 2 Peter 1:20

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