Matthew 18:14

Even so it is not the will of your Father who is in heaven, that one of these little ones should perish.
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Augustine of Hippo

AD 430
City of God, book xxii, ch. 29: They are called our Angels who are indeed the Angels of God; they are Gods because they have not forsaken Him; they are ours because they have begun to have us for their fellow citizens. As they now behold God, so shall we also behold Him face to face, of which vision John speaks, “We shall see Him as he is.” For by the face of God is to be understood the manifestation of Himself, not a member or feature of the body, such as we call by that name.
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Bede

AD 735
Ap. Anselm: The Lord found the sheep when He restored man, and over that sheep that is found there is more joy in heaven than over the ninety and nine, because there is a greater matter for thanksgiving to God in the restoration of man than in the creation of the Angels. Wonderfully are the Angels made, but more wonderfully man restored. Or; By the ninety-nine sheep, which He left on the mountains, are signified the proud to whom a unit is still wanting for perfection. When then He has found the sinner, He rejoices over him, that is, He makes his own to rejoice over him, rather than over the false righteous.

George Leo Haydock

AD 1849
Even so it is not. Here some may perhaps object, that since the Almighty does not wish any of his little ones to perish, he must consequently wish all to be saved, and therefore that all will be saved. Now this is not the case: the will of the Almighty is therefore sometimes frustrated in its effects, which is contrary to Scripture. To this objection, St. John Damascene replies, that in God we must distinguish two distinct wills; the one antecedent, the other consequent. A person wills a thing antecedently, when he wills it merely as considered in itself. For instance, a prince wishes his subjects to live, in as much as they are all his subjects. But a person wills a thing consequently, when he will a thing in consideration of some particular circumstance. Thus, though the king wishes all his subject to live, he nevertheless wills that some should die, if they turn traitors, or disorganize the peace of society. In the same manner, the Almighty wishes none of his little ones to perish, ...

Glossa Ordinaria

AD 1480
Ap. Anselm: Therefore are they not to be despised for that they are so dear to God, that Angels are deputed to be their guardians; “For I say unto you, that in heaven their Angels do always behold the face of my Father which is in heaven.”
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Gregory The Dialogist

AD 604
Hom. in Ev., 34, 12: But Dionysius says, that it is from the ranks of the lesser Angels that these are sent to perform this ministry, either visibly or invisibly, for that those higher ranks have not the employment of an outward ministry. Hom. in Ev., xxxiv, 3: This refers to the Creator of man Himself; for a hundredis a perfect number, and He had a hundred sheep when He created the substance of Angels and men. The Evangelist says they were left “on the mountains,” to signify that the sheep, which were not lost, abode on high. We must consider whence it is that the Lord declares that He has joy rather over the converted sinners, than over the righteous that stand. Because these last are often slothful and slack to practise the greater good works, as being very secure within themselves, for that they have committed none of the heavier sins. While on the other hand those who have their wicked deeds to remember, do often through the compunction of sorrow glow with the more heat in their l...

Hilary of Poitiers

AD 368
The Angels offer daily to God the prayers of those that are to be saved by Christ; it is therefore perilous to despise him whose desires and requests are conveyed to the eternal and invisible God, by the service and ministry of Angels. But by the one sheep is to be understood one man, and under this one man is comprehended the whole human race. He that seeks man is Christ, and the ninety and nine are the host of the heavenly glory which He left.
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Jerome

AD 420
The Lord had said, under the type of hand, foot, and eye, that all kin and connection which could afford scandal must be cut off. The harshness of this declaration He accordingly tempers with the following precept, saying, “Take heed that ye despise not one of these little ones;” i. e. As far as you may avoid despising them, but next to your own salvation seek also to heal them. But if ye see that they hold to their sins, it is better that ye be saved, than that ye perish in much company. High dignity of souls, that each from its birth has an Angel set in charge overit!. Others think that by the ninety and nine sheep are understood the number of the righteous, and by the one sheep the sinners according to that said in another place, “I am not come to call the righteous but sinners to repentance.”

John Chrysostom

AD 407
Do you see what a wall He has set around them, and what earnest care He takes of them that are contemptible and perishing, at once threatening incurable ills to them that make them fall, and promising great blessings to them that wait upon them, and take care of them, and bringing an example from Himself again and from the Father? Him let us also imitate, refusing none of the tasks that seem lowly and troublesome for our brethren's sake; but though we have to do service, though he be small, though he be mean for whom this is done, though the work be laborious, though we must pass over mountains and precipices, let all things be held endurable for the salvation of our brother. For a soul is an object of such earnest care to God, that He spared not His own Son. Romans 8:32 Wherefore I entreat, when morning has appeared, straightway as we come out of our house, let us have this one object in view, this earnest care above all, to rescue him that is in danger; I do not mean this dange...
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John Chrysostom

AD 407
If then God thus rejoices over the little one that is found, how do you despise them that are the objects of God's earnest care, when one ought to give up even one's very life for one of these little ones? But is he weak and mean? Therefore for this very cause most of all, one ought to do everything in order to preserve him. For even He Himself left the ninety and nine sheep, and went after this, and the safety of so many availed not to throw into the shade the loss of one. But Luke says, that He even brought it on his shoulders, and that There was greater joy over one sinner that repents, than over ninety and nine just persons. Luke 15:7 And from His forsaking those that were saved for it, and from His taking more pleasure in this one, He showed His earnestness about it to be great. Let us not then be careless about such souls as these. For all these things are said for this object. For by threatening, that he who has not become a little child should not so much as at all set foot ...

John Chrysostom

AD 407
Or otherwise; As to shun the evil, so to honour the good, has great recompense. Above then He had bid them to cut off the friendships of those that gave offence, here He teaches them to show honour and service to the saints. Or because the perfect are esteemed of many as little ones, as poor, namely, and despicable. Here He is speaking not of any Angels, but of the higher sort; for when He says, “Behold the face of my Father,” He shows that their presence before Godis free and open, and their honour great. He gives yet another reason weightier than the foregoing, why the little ones are not to be despised, “For the Son of Man is come to save that which was lost.”. And to this reasoning He adds a parable, in which He sets forth the Father as seeking the salvation of men, and saying, “What think you, If a man have ahundred sheep.”

Remigius of Rheims

AD 533
As much as to say, Despise not little ones, for I also for men condescended to become man. By “that which was lost,” understand the human race; for all the elements have kept their place, but man was lost, because he has broken his ordained place.
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Theophylact of Ochrid

AD 1107
. What man had a hundred sheep? Christ. For all of the reason-endowed creation, both angels and men, are the hundred sheep, of which Christ is the shepherd, not another sheep. For He is not a creature but the Son of God. So He left the ninety and nine in the heavens, and taking on the form of a servant He came to seek the one sheep, which is the fallen human nature. And He rejoices more over it than over the steadfastness of the angels. This shows in a few words how diligently God pursues the conversion of sinners, and rejoices more over them than over those who are constant in virtue.

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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