Matthew 17:22

And while they abode in Galilee, Jesus said unto them, The Son of man shall be betrayed into the hands of men:
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Cyril of Alexandria

AD 444
Therefore he brought the disciples to the mountain and showed them the glory with which he will shine on the universe in the future. Then coming down from the mountain he freed a person from a rough and evil spirit. It was altogether necessary for him to undergo his saving Passion for us and to suffer the violence of the Jews. When this happened, it was quite likely that the disciples would be alarmed and would ponder it and say among themselves: “He has raised so many from the dead by divine power, he commands the seas and winds, he overwhelms Satan with his words—how has he now been taken and fallen to the noose of his murderers? Then maybe we were deceived when we thought that he was God?” So that they should know the future fully and completely, therefore, he foretells to them the mystery of the Passion.

George Leo Haydock

AD 1849
They were troubled exceedingly, not being able to comprehend the mystery of Christ's sufferings and death, which were so opposite to the notions they had of the glorious kingdom of the Messias. (Witham) This grief was the consequence of their attachment to their divine Master. They were ignorant, as St. Mark and St. Luke notice, of the word that was spoken. They full well understood that he would be put to death, but did not sufficiently comprehend the shortness of his rest in the grave, the nature of his triumphant resurrection, nor the inestimable benefits which his death would bring on the world. (St. Chrysostom, hom. lix.)

Jerome

AD 420
Whenever the Lord speaks of future disaster, he always teaches its close relation with the happiness of redemption, so that when disasters suddenly come they do not terrify the apostles but may be borne by hearts that have premeditated them. If it saddens them because he is going to be killed, it ought to make them rejoice that it says, “On the third day he will arise again.” Further, their distress, in fact their great distress, does not come from lack of faith—elsewhere also they knew that Peter had been rebuked because he did not consider what belonged to God but what belonged to men—but because their love of their Master does not let them hear anything ominous or humiliating. .

John Chrysostom

AD 407
In case they say “Why do we delay here so long?” again he tells them about his Passion. Hearing of it, they did not even want to see Jerusalem …. Peter had been rebuked, those around Moses and Elijah had spoken with him and had called the thing glory, and … the Father had spoken from above; after so many miracles had taken place and the resurrection was close by (for he said that he would not long remain in death but would rise on the third day)—not even thus could they endure it. But “they were distressed,” and not simply “distressed” but “greatly distressed.” This happened because they did not yet recognize the power of what he said. But Mark and Luke imply it; the former saying that “they did not understand the saying and they were afraid to ask”; the latter saying that “it was concealed from them that they should not perceive it, and they were afraid to ask him about this saying.” Yet if they did not know it, why were they distressed? Because they were not totally ignorant. They kn...

John Chrysostom

AD 407
THAT is, to hinder their saying, "wherefore do we abide here continually," He speaks to them again of the passion; on hearing which they had no wish so much as to see Jerusalem. And it is remarkable how, when both Peter had been rebuked, and Moses and Elias had discoursed concerning it, and had called the thing glory, and the Father had uttered a voice from above, and so many miracles had been done, and the resurrection was at the doors (for He said, He should by no means abide any long time in death, but should be raised the third day); not even so did they endure it, but were sorry; and not merely sorry, but exceeding sorry.

Theophylact of Ochrid

AD 1107
He continually foretells the Passion, so that no one would think that He suffered unwillingly, and also, to train them not to be shaken by the unexpected when it occurred. To the sorrow He weds the joy that He will rise.

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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