And the multitude sat about him, and they said unto him, Behold, your mother and your brothers outside seek for you.
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Augustine of Hippo
It is he who said that no one belongs to his family except those who do the will of his Father. To be sure, he graciously included Mary herself in this number, for she was doing the will of his Father. Thus he spurned the earthly name of his mother in comparison to heavenly kinship…. Do not be ungrateful, pay your duty of gratitude to your mother, repay earthly favors by spiritual ones, temporal by eternal ones. Letter , To Laetus.
The brethren of our Lord were not the children of the blessed Virgin: nor were they the sons of St. Joseph by a former wife, as some pretend; but in the Scripture language, and in this place, we understand by brethren the relatives of Mary and Joseph. (Ven. Bede)