And they gave him to drink wine mingled with myrrh: but he received it not.
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Augustine of Hippo
AD 430
Be cautious and receive the words of our adversaries in order to spit them out, not to gulp them down and ingest them. Do in this instance what the Lord did when they offered him a bitter drink; he tasted it, and spat it out. So also should you, taste and spit.
The gall is mentioned with a view to express the bitterness of the potion. And wine mingled with myrrh is remarkable for its bitterness. The fact may also be that gall and myrrh together made the wine exceedingly bitter. Again, when Mark says that “he did not receive it,” we understand the phrase to denote that he did not receive it so as actually to drink it. He did taste it.
What sort of gall did they put in my mouth? “They gave him,” it says, “wine mixed with myrrh.” Myrrh is like gall in taste, and very bitter. “Is the Lord to be thus repaid by you?” Are these the offerings you make to your master, O vine? Catechetical Lectures
St. Matthew says mixed with gall; for gall is here used for bitterness, and wine that has myrrh in it is a very strong bitter; although, perhaps, both gall and myrrh might have been ingredients to increase the bitterness. (St. Augustine)
Or, in the confusion that was occasioned, some might have offered him one thing, some another; one person giving vinegar and gall, another wine mixed with myrrh. (Theophylactus)
Wine mingled with myrrh may perhaps be used for vinegar. (St. Jerome)
This was given to criminals, to lessen their torments. Our Lord was pleased to taste the bitterness, but he would not permit the relief which the admittance of the same into his stomach might have afforded. Thus also were the scriptures fulfilled: they gave me gall for my food, and in my thirst they gave me vinegar to drink. (Psalm lxviii.) (Ven. Bede)
He is given vinegar to drink and gall to eat—and who is he? Why, One who turned water into wine, who took away the taste of bitterness, who is all sweetness and desire. Oration , On the Son