Luke 10:3

Go your ways: behold, I send you forth as lambs among wolves.
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Ambrose of Milan

AD 397
Now these animals are at variance among themselves, so that the one is devoured by the other, the lambs by the wolves; but the good Shepherd has no fear of wolves for His flock. And therefore the disciples are appointed not to make prey, but to impart grace. For the watchfulness of the good Shepherd causes the wolves to attempt nothing against the lambs; He sends them as lambs amid wolves that that prophecy might be fulfilled, The wolf and the I lamb shall feed together. Or the heretics are compared to wolves. For wolves are beasts who lay in wait near the sheep folds, and prowl about the shepherds' cottages. They dare not enter the abodes of men, they pry out sleeping dogs, absent or slothful shepherds; they seize the sheep by the throat, that they may quickly strangle them; ravenous beasts, with bodies so stiff that they cannot easily turn themselves, but are carried along by their own impetus, and so are often deceived. If they are the first to see aman, it is said, they by a certai...

Ambrose of Milan

AD 397
He says this to the seventy disciples whom he appointed and sent out in pairs before his face. Why did he send them two by two? Pairs of animals were sent into the ark, that is, the female with the male, according to number, unclean but cleansed by the sacrament of the church…. Those animals are opposites, so that the one eats the other. A good shepherd does not know how to fear wolves for his flock, and therefore he sends those disciples not against a prey but to grace. The forethought of the good Shepherd prevents the wolves from harming the lambs. He sends lambs among wolves in order that the saying may be fulfilled, “Then wolves and lambs shall feed together.” ,

Bede

AD 735
Or He especially gives the name of wolves to the Scribes and Pharisees, who are the Jewish clergy.
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Cornelius a Lapide

AD 1637
Go your ways: behold, I send you forth as lambs among wolves. That by your innocent and holy lives, through the power of My grace working in you, you may change the wolf into the lamb, i.e, convert evil men from the error of their way. Fear not, therefore, for under My protection no harm can befall you. For, as S. Ambrose says, "the good Shepherd takes care that the wolves do His flock no harm."
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Cyril of Alexandria

AD 444
Thus He had already commanded them to have no care for these persons, when He said, I send you as lambs among wolves. And He also forbade all care about what is external to the body, by saying, Take neither purse nor scrip. Nor did He allow men to take with the many of those things which were not attached to the body. Hence He adds, Nor shoes. He not only forbade them to take purse and scrip, but He did not allow them to receive any distraction in their work, such as interruption by greetings on their way. Hence He adds, Salute no one by the way. Which had long ago been said by Elisha. As if He said, Proceed straight on to your work without exchanging blessings with others. For it is a loss to waste the time which is fitter for preaching, in unnecessary things.

Cyril of Alexandria

AD 444
How then does he command the holy apostles, who are innocent men and “sheep,” to seek the company of wolves, and go to them of their own will? Is not the danger apparent? Are they not set up as ready prey for their attacks? How can a sheep prevail over a wolf? How can one so peaceful conquer the savageness of beasts of prey? “Yes,” he says, “for they all have me as their Shepherd: small and great, people and princes, teachers and students. I will be with you, help you, and deliver you from all evil. I will tame the savage beasts. I will change wolves into sheep, and I will make the persecutors become the helpers of the persecuted. I will make those who wrong my ministers to be sharers in their pious designs. I make and unmake all things, and nothing can resist my will.” Commentary on Luke, Homily

Gregory The Dialogist

AD 604
For many when they receive the right of rule, are vehement in persecuting their subjects, and manifesting the terrors of their power. And since they have no bowels of mercy, their desire is to seem to be masters, forgetting altogether that they are fathers, changing an occasion for humility, into an exaltation of power. We must on the other hand consider, thatas lambs are sent among wolves because they preserve the feeling of innocence, so we should make no malicious attacks. For he who undertakes the office of preacher ought not to bring evils upon others, but to endure them; who although at times an upright zeal demands that he should deal harshly with his subjects, should still inwardly in his heart love with a fatherly feeling those whom outwardly he visits with censure. And that ruler gives a good example of this, who never submits the neck of his soul to the yoke of earthly desire. Hence it is added, Carry neither purse nor scrip. For the preacher (of the Gospel) ought to have su...

Gregory the Theologian

AD 390
The sum of which is, that men ought to be so virtuous that the Gospel should make no less progress through their way of life than their preaching. The Lord gave them these commands also for the glory of the word, lest it should seem that enticements could more prevail over them. He wished them also not to be anxious to speak to others.
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Isodore of Seville

AD 636
Denoting the simplicity and innocence in His disciples. For those who were riotous, and by their enormities did despite to their nature, He calls not lambs, but goats.
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John Chrysostom

AD 407
For their comfort amid every danger was the power of Him who sent them. And therefore said He, Behold, I send you; as if he said, This will suffice for your consolation, this will be enough to make you hope, instead of fearing the coming evils which He signifies, adding, as lambs among wolves. For this was a clear announcement of glorious triumph, that the disciples of Christ, when surrounded by their enemies as lambs among wolves, should still convert them.
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Lucius Caecilius Firmianus Lactantius

AD 320
To His everlasting mercy ought we to render thanks, that, having at length looked on the earth, He deigned to collect again and to restore His flock, partly laid waste by ravenous wolves, and partly scattered abroad, and to extirpate those noxious wild beasts who had trod down its pastures, and destroyed its resting-places.
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Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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