John 8:21

Then said Jesus again unto them, I go my way, and you shall seek me, and shall die in your sins: where I go, you cannot come.
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Augustine of Hippo

AD 430
In accordance with what was just, He said that no man laid hands on Him, because His hour was not yet come; He now speaks to the Jews of His passion, as a free, and not acompulsory sacrifice on His part: Then said Jesus again to them, I go My way. Death to our Lord was a return to the place whence He had come. You shall seek Me, then, He says, not from compassionate regret, but from hatred: for after He had departed from the eyes of men, He was sought for both by those who hated, and those who loved Him: theone wanting to persecute, the other to have His presence. And that you may not think that you shall seek Me in a good sense, I tell you, You shall die in your sin. This is to seek Christ amiss, to die in one’s sin: this is to hate Him, from Whom alone comes salvation. He pronounces sentence on them prophetically, that they shall die in their sins. This He tells His disciples in another place; without saying to them, however, You, shall die in your sin, He only says Whither I go, you...

Augustine of Hippo

AD 430
1. The lesson of the holy Gospel which preceded today's had concluded thus: that the Lord spoke, teaching in the treasury, what it pleased Him, and what you have heard; and no one laid hands on Him, for His hour was not yet come. Accordingly, on the Lord's day we made our subject of discourse what He Himself thought fit to give us. We indicated to your Charity why it was said, His hour was not yet come, lest any in their impiety should have the effrontery to suspect Christ as laid under some fatal necessity. For the hour was not yet come when by His own appointment, in accordance with what was predicted regarding Him, He should not be forced to die unwillingly, but be ready to be slain. 2. But of His own passion itself, which lay not in any necessity He was under, but in His own power, all that He said in His discourse to the Jews was, I go away. For to Christ the Lord's death was His proceeding to the place whence He had come, and from which He had never departed. I go away, said H...
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Bede

AD 735
The connection of these words is such, that they might have been spoken at one place and one time, or at another place and another time: as either nothing at all, or some things, or many may have intervened. Note: sinis in the singular number, your in the plural; to express one and the same wickedness in all. And Who was before the world, whereas they were of the world, having been created after the world had begun to exist.
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Cornelius a Lapide

AD 1637
Jesus therefore said to them again. (1.) Some think that "therefore" only indicates the beginning of a new discourse. (2.) Origen thinks it indicates that what follows was spoken by Christ at the same time and place. (3.) Maldonatus refers it to verse19 , Ye neither know Me nor My Father. The time therefore will come for you to know Me as God, but ye will not find Me, for ye will die in your sins. (4.) Rupertus and Toletus refer it more appositely, to the words immediately preceding. Because He saw that the Pharisees understood, and were angered at His words, He adds, I go My way, &c. He had said the same before ( John 7:33), first to the officers, and then to the Pharisees. I go My way, that is out of this life to My Father by My cross and death. "Death was to Christ," says S. Augustine, "a going forth, for He abode not in the world, but passed through it to heaven and immortal life." And ye shall seek Me, i.e, ye shall seek another Messiah, and will not find him, says Toletus, for ...

Cyril of Alexandria

AD 444
and whither I go, YE cannot come. Not only does He say that they shall die in their sins, but declares clearly that, ascending not to the mansions above, they will remain outside of the good things of the kingdom: for they who received not Him Who came from above, how could they also follow Him ascending up? Double therefore is the punishment to them who believe not, and not in any single thing their loss. For just as they who have fallen into bodily loss of health must needs suffer and endure the trials of the suffering and besides be deprived of the pleasures of health; so and not otherwise do they who have departed into Hades, and there undergo punishment proportionate to the sins, both endure the state of punishment and lose the enjoyment of the hope of the saints. Most excellently then does our Lord Jesus Christ say not only that they shall die in their sins, but also that they shall not mount up to the mansions above: for binding them as by a twofold cord, does He haste to dra...

Cyril of Alexandria

AD 444
He said therefore unto them again, I go My way, and ye shall seek Me and shall die in your sins. That we must needs take hold of the present time for whatever one may receive profit from to oneself, does Christ herein well declare unto us. For to be too late in what is good and to take after-counsel for what is profitable, clearly brings no gain but ministers wailing befitting the neglect. Our Lord therefore being good and gracious, as it is written, both bears with those who dishonour Him and aids those who insult Him and is found as God superior to all the littleness of man. Yet does He for their good threaten to depart from them, and says plainly I go My way, that He may implant in them a more resolved mind, and that they considering that they ought not to leave their Redeemer when present frustrate of His work, He may whet them to pass on to the faith and may make them now at length more ready unto obedience. And having cried out, I go My way, and threatened departure from the w...

George Leo Haydock

AD 1849
I go my way, and you shall seek me See the foregoing chapter, ver. 34. (Witham)
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John Chrysostom

AD 407
Why says He this continually? To shame and terrify their souls; for observe what fear this saying caused in them. Although they desired to kill Him that they might be rid of Him, they yet ask, whither He goes, such great things did they imagine from the matter. He desired also to show them another thing, that the deed would not be effected through their force; but He showed it to them in a figure beforehand, and already foretold the Resurrection by these words.
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John Chrysostom

AD 407
As if to say, No wonder that you think as you do, seeing you are carnal, and understand nothing spiritually. I am from above. Or He says, I am not of this world, with reference to worldly and vain thoughts. For if He came in order to take away sin, and a man cannot put that off, except by washing, and cannot be baptized except he believe; it follows, that he who believers not must pass out of this life, with the old man, i.e. sin, within him: not only because he believes not, but because he departs hence, with his former sins upon him.

Theophilus of Antioch

AD 184
He shows here that He will rise again in glory, and sit at the right hand of God. I affect nothing worldly, nothing earthly: I could never come to such madness as to kill Myself. Apollinarius, however, falsely infers from these words, that our Lord's body was not of this world, but came down from heaven. Did the Apostles then, to whom our Lord says below, You are not of this world, derive all of them their bodies from heaven? In saying then, 1 am not of this world, He must be understood to mean, I am not of the number of you, who mind earthly things.

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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