Galatians 4:29

But as then he that was born after the flesh persecuted him that was born after the Spirit, even so it is now.
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Cornelius a Lapide

AD 1637
He that was born after the flesh. Ishmael, born naturally of Hagar, persecuted Isaac, born supernaturally of Sarah, according to the Divine promise, and so a type of the spiritual children of the New Law. The reference is to Gen. xxi9. From a comparison of these two passages it is evident that the mockery mentioned was a sort of persecution, the sort of sport that cats have with mice. So in 2 Samuel 2:14: "Abner said to Joab, Let the young men now arise and play before us," where the play was a mortal combat. Jerome and others think that the reason why Ishmael persecuted Isaac was because his envy was stirred up by the festivities indulged in at Isaac"s weaning, and because he was jealous of the birthright assigned to his brother by promise. Hence it appears that he was hostile to the promised Seed, i.e, to Christ. So it is now. As formerly Ishmael mocked and persecuted Isaac, so now have the Jews mocked and crucified Christ, the King of liberty, and are still pursuing with bitter ha...

George Leo Haydock

AD 1849
St. Paul makes another observation upon this example of Ismael and Isaac: that as Ismael was troublesome to Isaac, for which he and his mother were turned out of the family, so also now the Jews insulted and persecuted the Christians, who had been Gentiles; but God will protect them as heirs of the blessings promised: they shall be accounted the spiritual children of Abraham, while the Jews, with their carnal ceremonies, shall be cast off. (Witham) This, says St. Augustine, is a figure of heretics, (who are the children of the bond-woman) unjustly persecuting the Catholic Church. (Ep. 48.)

Jerome

AD 420
Ishmael, the elder brother, persecuted him while still a nursing infant, claiming for himself the prior right of circumcision and the inheritance of the firstborn…. And it is aptly said that he who is born according to nature persecutes the spiritual. The spiritual one never persecutes the natural one but forgives him like an untutored brother, for he knows that he may progress. –.

John Chrysostom

AD 407
What! Does all this consolation consist in showing that freemen are persecuted by bond-men? By no means, he says, I do not stop here, listen to what follows, and then, if you be not pusillanimous under persecution, you will be sufficiently comforted. And what is it that follows? Cast out the son of the handmaid, for he shall not inherit with the son of the freewoman. Behold the reward of tyranny for a season, and of reckleness out of season! The son is cast out of his father's house, and becomes, together with his mother, an exile and a wanderer. And consider too the wisdom of the remark; for he says not that he was cast forth merely because he persecuted, but that he should not be heir. For this punishment was not exacted from him on account of his temporary persecution, (for that would have been of little moment, and nothing to the point,) but he was not suffered to participate in the inheritance provided for the son. And this proves that, putting the persecution aside, this very thi...

John Chrysostom

AD 407
“And what sort of freedom is this,” someone might ask, “when the Jews oppress and beat the faithful, and those who are reckoned free are persecuted?” For that is what happened then, as the faithful were persecuted. “But do not let even this discourage you, for this too he included beforehand in the type.”

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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