In the meantime, when there were gathered together an innumerable multitude of people, so much that they tread one upon another, he began to say unto his disciples first of all,
Beware of the leaven of the Pharisees, which is hypocrisy.
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Cyril of Alexandria
AD 444
Being angry at this reproof, it says they began to urge him vehemently. This means to attack him with cunning, oppose him and show their hatred of him. They also tried, it says, to silence him about many things. What again is the meaning of their silencing him? It is that they required him to answer immediately and without consideration their wicked questions, expecting that he would fall and say something objectionable. They did not know that he was God. They despised him, were proud and disrespectful. Christ told his friends, that is, his disciples, to beware of the leaven of the Pharisees and scribes, meaning by leaven their false pretense. Hypocrisy is hateful to God and humanity. It does not bring a reward, and it is utterly useless for the salvation of the soul. It is rather the cause of its damnation. Although sometimes it may escape detection for a little while, before long, it is sure to be uncovered and bring disgrace on them. It is like an unattractive woman when she is stripped of that external embellishment which she produced by artificial means. Commentary on Luke, Homily