For he has made him, who knew no sin, to be sin for us; that we might be made the righteousness of God in him.
All Commentaries on 2 Corinthians 5:21 Go To 2 Corinthians 5
Ambrose of Milan
AD 397
But if you hold to the letter, so as to think from what is written, namely, the Word was made flesh, that the Word of God was turned into flesh, do you not deny that it is written of the Lord that he did not make sin but was made sin? So, was the Lord turned into sin? Not so, but, since he assumed our sins, he is called sin. For the Lord is also called an accursed thing, not because the Lord was turned into an accursed thing but because he himself took on our curse. He says: “For he is accursed that hangs on a tree.” … It is written that he was made sin, that is, not by the nature and operation of sin … ; but that he might crucify our sin in his flesh, he assumed for us the burden of the infirmities of a body already guilty of carnal sin.