Let not sin therefore reign in your mortal body, that you should obey it in its lusts.
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Ambrosiaster
AD 400
The body is mortal because of the sin of Adam, but by faith in Christ we believe that it will be immortal. But in order for it to inherit the promise, Paul says that it must not listen to the voice of sin, so that sin may not reign in our mortal body. For it reigns as long as it is in control. But if it does not reign, the body will no longer appear to be mortal, because it dwells in the hope of eternal life. Paul did not say that the body is mortal because it will disintegrate but because of the pain of hell, so that the man who is sent to hell is said to be mortal because whoever hearkens to sin will not escape the second death, from which the Savior has delivered those who believe in him. Therefore, the mortal body refers to the entire human being because those who hearken to sin are said to be mortal. For Scripture says: “The soul which sins shall surely die,” which means the whole human being. For nobody will be judged apart from his body. Commentary on Paul’s Epistles.