And no man in heaven, nor in earth, neither under the earth, was able to open the scroll, neither to look thereon.
All Commentaries on Revelation 5:3 Go To Revelation 5
Andreas of Caesarea
AD 637
This means that neither angels nor human beings, those in the flesh, nor the saints who had departed from the flesh are able to understand the knowledge of the divine judgments, except the lamb of God, by His presence releasing the obscurity of the things prophesied about him.