Then said Mary unto the angel, How shall this be, seeing I know not a man?
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Gregory of Nyssa
AD 394
O blessed is that womb which because of the overflowing purity of the Virgin Mary has drawn to itself the gift of life! For in others scarcely indeed shall a pure soul obtain the presence of the Holy Spirit, but in her the flesh is made the receptacle of the Spirit.
Or he says, overshadow you, because as a shadow takes its shape from the character of those bodies which go before it, so the signs of the Son's Deity will appear from the power of the Father. For as in us a certain life-giving power is seen in the material substance, by which man is formed; so in the Virgin, has the power of the Highest in like manner, by the life-giving Spirit, taken from the Virgin's body a fleshly substance inherent in the body to form a new man. Hence it follows, Therefore also that holy thing which shall be born of you.