Therefore let all the house of Israel know assuredly, that God has made that same Jesus, whom you have crucified, both Lord and Christ.
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Ambrose of Milan
AD 397
that God has made this same Jesus:
It was not the Godhead, but the flesh, that was crucified. This, indeed, was possible, because the flesh allowed of being crucified. It follows not, then, that the Son of God is a created being
For on Christ our Savior we confess the anointing to have been performed, not however figuratively, (as formerly on kings by the oil,) and as if by prophetic grace, but the Savior as man in the form of a servant, was anointed by the Holy Spirit as God He Himself by His Holy Spirit anoints those that believe in Him.
that God has made this same Jesus:
has made; i.e. has ordained: so that there is nothing about (οὐσίωσις) communication of substance here, but the expression relates to this which has been mentioned.
this same Jesus, whom you crucified:
He does well to end with this, thereby agitating their minds. For when he has shown how great it is, he has then exposed their daring deed, so as to show it to be greater, and to possess them with terror. For men are not so much attracted by benefits as they are chastened by fear.
Hereby it is also clear that Peter’s saying that God has made this same Jesus, is to be referred to the Son in His human nature, in which He began to have in time what in His nature He had from eternity.