Acts 16:6

Now when they had gone throughout Phrygia and the region of Galatia, and were forbidden of the Holy Spirit to preach the word in Asia,
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George Leo Haydock

AD 1849
They were forbidden by the Holy Spirit, to go, and preach at that time in the Lesser Asia . (Witham) Forbidden. Why? Because they were not yet prepared to receive the gospel; or, perhaps, these provinces were reserved for St. John, as Bithynia was for St. Luke. (Menochius) St. Leo compares this question to many others respecting the inscrutable judgments of God. Why did not the Son of God come into the world many ages before? Why did he suffer so many to die in ignorance? Why are there yet so many in infidelity? Why, in one family, does one believe and is converted, while another remains in darkness, and crime? Who shall account for the exercise he pleases to make of his rigour, or his mercy, when all were justly victims of the former? (St. Leo, de vocat. Gentium. lib. ii. chap. 2)

John Chrysostom

AD 407
having left Phrygia and Galatia, they hastened into the interior. For, it says, After they had come to Mysia, they assayed to go into Bithynia: but the Spirit suffered them not.

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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