I had no rest in my spirit, because I found not Titus my brother: but taking my leave of them, I went from there into Macedonia.
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Ambrosiaster
AD 400
Lacking the consolation of Titus’s presence Paul found the work unbearable, because there was so much opposition to him. For although some people had opened their hearts and accepted the Word of God, there were many unbelievers who reacted with impudent hostility. One lone voice could not teach the new believers and fend off these attacks at the same time. Therefore Paul said goodbye to those who had received him and left for Macedonia. Commentary on Paul’s Epistles.
Paul did not say that the absence of Titus hindered the salvation of those who were about to convert, nor that he neglected them for this reason, but that he continued to be concerned for Titus, showing thereby how serious a matter a brother’s absence is.