2 Corinthians 12:8

For this thing I besought the Lord three times, that it might depart from me.
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Ambrosiaster

AD 400
Although he asked three times, his request was not granted. It is not that he was disregarded but that he was making a plea which was against his own best interests. Commentary on Paul’s Epistles.

Cornelius a Lapide

AD 1637
For this thing I besought the Lord thrice . . . and He said unto me. Three is the number symbolic of multitude and universality. The answer meant that though he was weak in himself, yet in God he might be strong enough to overcome this temptation. It, hence appears that Paul was not heard, and was not freed from his thorn. S. Augustine gives the reason (Enarr. in Ps. cxxxi.). He says: "As when some disagreeable medicine is brought to one that is sick, and he asks the physician to take it away; whereupon the physician comforts him and urges him to have patience, because he knows that the medicine is good for him, so does God here deal with Paul." As a physician from vipers" flesh makes a conserve against vipers" poison, so does God, out of our weakness, form a medicine against weakness, and makes one lust of the flesh a remedy against another, as, e.g, this thorn of the flesh was a preservative against pride.

John Chrysostom

AD 407
Accordingly, whether we have our requests granted or not, let us persist in asking and render thanks not only when we gain what we ask but also when we fail to. Failure to gain, you see, when that is what God wants, is not worse than succeeding; we do not know what is to our advantage in this regard in the way he does understand. The result is, then, that succeeding or failing we ought to give thanks. Why are you surprised that we don’t know what is to our advantage? Paul, a man of such quality and stature, judged worthy of ineffable blessings, did not know what was advantageous in his requests: when he saw himself beset with trouble and diverse tribulations, he prayed to be rid of them, not once or twice but many times. “Three times I asked the Lord,” he says… . “Three” means he asked frequently without success. So let us see how he was affected by it: surely he didn’t take it badly? He didn’t turn fainthearted, did he? He didn’t become dispirited, did he? Not at all. On the contrary,...

John Chrysostom

AD 407
Three times means repeatedly. Paul could not bear the plots which were going on behind his back, and he sought to be delivered from them.

John Chrysostom

AD 407
That is, oftentimes. This also is a mark of great lowliness of mind, his not concealing that he could not bear those insidious plottings, that he fainted under them and was reduced to pray for deliverance.

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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