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Genesis 3:22

And the LORD God said, Behold, the man is become as one of us, to know good and evil: and now, lest he put forth his hand, and take also of the tree of life, and eat, and live forever:
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Ephrem The Syrian

AD 373
Having finished this it says, "Behold, Adam has become like one of us, knowing good and evil." [ Gen. 3:22 ] By saying that "he has become like one of us," Scripture also revealed symbolically something about the Trinity. But at the same time God was actually addressing Adam ironically, seeing that Adam had been told, "you will become like God, knowing good and evil." However, although Adam and Eve became aware of both these things from eating the fruit, prior to the fruit they were in practice only aware of the good, hearing about evil by report, but after eating it there was a change, so that they only heard by report of the good, whereas they tasted evil in practice. For the glory in which they had been wrapped left them, and the pains which had previously been kept away from them now dominated them. "And now, lest he stretch out his hand and take from the fruit of the Tree of Life as well, and eat it and live for ever..." [ Gen. 3:22 ] For if he had the audacity to eat of the...

Ephrem The Syrian

AD 373
If Adam had rashly eaten from the tree of knowledge he was commanded not to eat, how much faster would he hasten to the tree of life about which he had not been so commanded? But it was now decreed that they should live in toil, in sweat, in pains and in pangs. Therefore, lest Adam and Eve, after having eaten of this tree, live forever and remain in eternal lives of suffering, God forbade them to eat, after they were clothed with a curse, that which he had been prepared to give them before they incurred the curse and when they were still clothed with glory. .

Ephrem The Syrian

AD 373
God said, “Behold, Adam has become like one of us, knowing good and evil.” Even though by saying, “He has become like one of us,” he symbolically reveals the Trinity, the point is rather that God was mocking Adam in that Adam had previously been told, “You will become like God, knowing good and evil.” Now even though after they ate the fruit Adam and Eve came to know these two things, before they ate the fruit they had perceived in reality only good, and they heard about evil only by hearsay. After they ate, however, a change occurred so that now they would only hear about good by hearsay, whereas in reality they would taste only evil. For the glory with which they had been clothed passed away from them, while pain and disease that had been kept away from them now came to hold sway over them. –.

George Leo Haydock

AD 1849
Behold Adam This was spoken by way of reproaching him with his pride, in affecting a knowledge that might make him like to God. (Challoner) "These are the words of God, not insulting over man, but deterring others from an imitation of his pride. "(St. Augustine, de Gen. xi. 39.) For ever. The sentence is left imperfect: (Calmet) but by driving man from Paradise, God sufficiently showed how he would prevent him from eating of the tree of life, (Haydock) which Adam had not yet found. As he was now condemned to be miserable on earth, God, in mercy, prevented him from tasting of that fruit, which would have rendered his misery perpetual. (Menochius) He would suffer him to die, that, by death, he might come, after a life of 930 years, spent in sorrow and repentance, to the enjoyment of himself. (Haydock) Lest perhaps. God does not exercise his absolute power, or destroy free-will, but makes use of ordinary means and precautions, to effect his designs. (St. Augustine) (Worthington)

John Cassian

AD 435
And how will that statement of the Lord stand, after the sin of the first man: “Behold, Adam is become like one of us, knowing good and evil?” For he must not to be thought to have been such before the sin that he was wholly ignorant of good. Otherwise, it must be admitted that he was created like an irrational and senseless animal; and this is quite absurd and foreign to the Catholic faith. No, rather, according to the pronouncement of the most wise Solomon, “God made man right,” that is, to enjoy continually the knowledge of good alone. But they sought many thoughts. So they were made, as it was said, “knowing good and evil.” After the fall, therefore, Adam conceived a knowledge of evil, which he did not have. But he did not lose the knowledge of good, which he did have. –.

John Chrysostom

AD 407
See again God's considerateness. "the Lord God said," the text says, "'Lo, Adam has become like one of us in knowing good and ill." ' Do you see how remarkable is the ordinariness of the expression? Let us, however-, take it all in a sense befitting God. You see, the intention at this point is to remind us through these words of the deception practiced on them by the devil through the instrumentality of the serpent. I mean, that was when that creature said, "'If you eat, you will be like gods,'" and they presumed to taste it in the hope of achieving this equality. Hence also God wanted again to make them ashamed, to bring them to a sense of their- sins and to show them the gravity of their disobedience and the excess of the deception, said, "'Lo, Adam has become like one of us.'" Great is the reproach in this sentence, capable of touching the heart of the transgressor. Was this your reason, he is saying, for despising my commandment, that you had notions of equality? Lo, you have becom...

John Chrysostom

AD 407
It is now necessary to say why, even though man did not receive the knowledge from the tree, it is called “the tree that gives the knowledge of good and evil;” for it is not a trifle to learn why a tree has such a name. In fact the devil said, “On the day when you eat of the fruit of the tree, your eyes will be opened and you will be like gods, knowing good and evil.” How can you maintain, you ask me, that it did not provide him with the knowledge of good and evil? Who said, in fact, that it provided him with this knowledge? The devil, you will answer. So do you put forward the testimony of the enemy and the conspirator? The devil said, “You will be gods.” Did they really become gods? Therefore, since they did not become gods, they did not receive the knowledge of good and evil either. For the devil is a liar and never speaks the truth. In fact the Gospel says, “He never stays in the truth.”

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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