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Daniel 7:8

I considered the horns, and, behold, there came up among them another little horn, before whom there were three of the first horns plucked up by the roots: and, behold, in this horn were eyes like the eyes of man, and a mouth speaking great things.
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Aquinas Study Bible

AD 2017
The fourth beast being the Roman Empire, has ruled throughout different stages of history. Though ancient Rome is no longer in power, there will be a continuation, a new Rome, that will rule the world in the same manner as before. The ten horns are 10 kings of Rome, in which the Antichrist (little horn) will come up and remove (pluck up) three who are ruling at that time, while the other seven will willfully submit to his rule. This vision is very similar to what St. John saw in Revelation 13:2, And the beast that I saw was like a leopard, its feet were like a bear's, and its mouth was like a lion's mouth. And to it the dragon gave his power and his throne and great authority." Daniel saw a vision of four separate animals, not one beast composed of parts from three animals, which means that the Antichrist's rule will include all of the areas represented by these animals — Greece, Persia and Mesopotamia.

George Leo Haydock

AD 1849
Little horn. This is commonly understood of antichrist. It may also be applied to that great persecutor, Antiochus Epiphanes, as a figure of antichrist. (Challoner) He was the youngest son of Antiochus the great, and was a hostage of Rome. While he was returning, his elder brother died, and Epiphanes excluded his son Philometor, of Egypt, and the usurper Heliodorus. He also defeated three, Philometor, on the south; Artaxias, king of Armenia, on the east; and the strength, or God's people, ver 24., and chap. viii. 9. Man. He gained several at first, by his affability. Things: blasphemy, 1 Machabees i. 23, 43. (Calmet)

Hippolytus of Rome

AD 235
"I considered the horns. That is to say, I looked intently at the beast, and was astonished at everything about it, but especially at the number of the horns. For the appearance of this beast differed from that of the other beasts in kind.

Jerome

AD 420
Porphyry vainly surmises that the little (p. 531) horn which rose up after the ten horns is Antiochus Epiphanes, and that the three uprooted horns out of the ten are (A) Ptolemy VI (surnamed Philometer), Ptolemy VII (Euergetes), and Artaraxias, King of Armenia. The first two of these kings died long before Antiochus was born. Against Artarxias, to be sure, we know that Antiochus indeed waged war, but also we know that Artarxias remained in possession of his original kingly authority. We should therefore concur with the traditional interpretation of all the commentators of the Christian Church, that at the end of the world, when the Roman Empire is to be destroyed, there shall be ten kings who will partition the Roman world amongst themselves. Then an insignificant eleventh king will arise, who will overcome three of the ten kings, that is, the king of Egypt, the king of [North] Africa, and the king of Ethiopia, as we shall show more clearly in our later discussion. Then after they have...

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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