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Genesis 3:15

And I will put enmity between you and the woman, and between your seed and her seed; he shall bruise your head, and you shall bruise his heel.
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Irenaeus of Lyons

AD 202
Christ completely renewed all things, both taking up the battle against our enemy and crushing him who at the beginning had led us captive in Adam, trampling on his head, as you find in Genesis that God said to the serpent, “I will put enmity between you and the woman, and between your seed and the seed of the woman. He will be on the watch for your head, and you will be on the watch for his heel.” From then on it was proclaimed that he who was to be born of a virgin, after the likeness of Adam, would be on the watch for the serpent’s head. This is the seed of which the apostle says in the letter to the Galatians, “The law of works was established until the seed should come to whom the promise was made.” He shows this still more clearly in the same epistle when he says, “But when the fullness of time was come, God sent his Son, made of a woman.” The enemy would not have been justly conquered unless it had been a man made of woman who conquered him. For it was by a woman that he had power over man from the beginning, setting himself up in opposition to man. Because of this the Lord also declares himself to be the Son of Man, so renewing in himself that primal man from whom the formation of man by woman began, that as our race went down to death by a man who overcame, and as death won the palm of victory over us by a man, so we might by a man receive the palm of victory over death. .
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Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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