1 Timothy 6:20

O Timothy, keep that which is committed to your trust, avoiding profane and vain utterances, and oppositions of what is falsely called knowledge:
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Basil the Great

AD 379
But we must proceed to attack our opponents, in the endeavor to confute those “oppositions” advanced against us which are derived from “knowledge falsely socalled.” It is not permissible, they assert, for the Holy Spirit to be ranked with the Father and the Son, on account of the difference of his nature and the inferiority of his dignity. Against them it is right to reply in the words of the apostles, “We ought to obey God rather than men. . ...
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Clement Of Alexandria

AD 215
Pride and opinionated views have corrupted philosophy. In the same way, false knowledge, though it bears the same name, has corrupted true knowledge. The apostle writes of it, saying, “Timothy, guard what has been entrusted to you. Avoid the godless chatter and contradictions of what is falsely called knowledge, for by professing it some have missed the mark as regards the faith.” Because this verse exposes them, the heretics regard the letters to Timothy as inauthentic. Well, if the Lord is “truth” and “the wisdom and power of God,” as in fact he is, it would be demonstrated that the true knower is the one who has come to know Son and his Father through him. .. ...

Clement Of Alexandria

AD 215
As, then, philosophy has been brought into evil repute by pride and self-conceit, so also ghosts by false ghosts called by the same name; of which the apostle writing says, "O Timothy, keep that which is committed to thy trust, avoiding the profane and vain babblings and oppositions of science (gnosis) falsely so called; which some professing, have erred concerning the faith." ...
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Cyril of Jerusalem

AD 386
I have many other testimonies from holy Scripture to the fact that the kingdom of Christ endures throughout all ages. But I will content myself with what I have said, because the day wears on. And do you, my hearers, worship him alone as king, and flee every misguided heresy…. Flee the false Christ, and look for the true. You have been taught the way to be among those on his right hand at the judgment. Retain “that which is committed to you” concerning Christ, and be adorned with good works. So you will stand with a good courage before the Judge and thereafter inherit the kingdom of heaven. ...

Eusebius of Caesarea

AD 339
Besides this, the same man [Hegesippus], when relating the events of these times, adds that until then the church had remained a pure and undefiled virgin, since those who attempted to corrupt the sound rule of the Savior’s preaching, if any did exist, until then lurked somewhere in obscure darkness. But when the sacred band of the apostles had received an end of life in various ways, and the generation of those who were deemed worthy to hear the divine wisdom with their own ears had passed away, then the league of godless error took its beginnings because of the deceit of heretical teachers who, since none of the apostles still remained, attempted henceforth barefacedly to proclaim in opposition to the preaching of truth “the knowledge falsely socalled.” ...

George Leo Haydock

AD 1849
O Timothy, keep that which is committed of words: (in the Greek empty, vain, babbling). The apostle here condemns new words, which change the doctrine; but sometimes to express the ancient doctrine, new words may be found necessary, as those of trinity, incarnation, consubstantiality, transubstantiation as St. Athanasius, St. Augustine, and others observed. See 2 Timothy i. 14. Oppositions of knowledge falsely so called. St. Chrysostom understands in particular the errors of the Gnostics, so called from the same Greek word, who were the successors of Simon Magus. But they perhaps not having the name when St. Paul wrote, we may rather understand heretics in general, who all pretend to an uncommon knowledge in Scriptures, when they follow their own private judgment, and so fall from the faith. (Witham) Keep the deposit, viz. of faith, which has been committed to thee. Throughout this whole epistle the apostle beseeches Timothy, in the most earnest manner, as a guardian of the faith, to...

Hippolytus of Rome

AD 235
For it seems expedient that we, making an onslaught upon the opinion which constitutes the prime source of (contemporaneous) evils, should prove what are the originating principles
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Irenaeus of Lyons

AD 202
In fine, they have a name derived from Simon, the author of these most impious doctrines, being called Simonians; and from them "knowledge, falsely so called". 1. In the first book, which immediately precedes this, exposing "knowledge falsely so called". of language, they style ignorance of the truth knowledge: and Paul well says ...
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Jerome

AD 420
The apostle labors, and, although he has lived blameless, according to the justice that is from the law, he counts everything as worthless for Christ, that he may be found in Christ, not having his own justice which is from the law but that which is from the faith of Christ, from God…. Therefore, we are saved, not by the power of the free will but by the mercy of God. And, lest you think that the truth of faith can be subverted by vain argumentations which raise questions in the minds of the hearers, the same apostle writes to Timothy, “O Timothy, guard the trust and keep free from profane novelties in speech and the contradictions of socalled knowledge, which some have promised and have fallen away from the faith.” For the goodness and mercy of our Savior have saved us, not by reason of good works that we did ourselves but according to his mercy, in order that, justified by his grace, we may be heirs in the hope of life everlasting. ...

John Cassian

AD 435
The psalmist also declares that this is the sequence we must follow. He says, “Blessed are those who are unsullied upon their journey, who walk in the law of the Lord. Blessed are those who pay heed to his witness.” … In this way he shows clearly that no one can manage to engage in the correct scrutiny of God’s Word unless in his daily life he proceeds unstained along the road of Christ. Therefore those whom you have mentioned cannot possess this knowledge if they are unclean. What they have is a false socalled lore, the kind about which the apostle has this to say, “O Timothy, guard what has been given to you. In all that you say avoid profane novelties and the claims of a falsely named knowledge.” ...

John Chrysostom

AD 407
O Timothy, keep that which is committed to your trust. Let it not suffer diminution. It is not your own. You are entrusted with the property of another, do not lessen it. Avoiding profane and vain babblings, and oppositions of science falsely so called. Well did he thus call it. For where there is not faith, there is not knowledge; when anything springs from our reasonings, it is not knowledge. Or perhaps he says this, because some then assumed the name of Gnostics, as knowing more than others. ...
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Leo of Rome

AD 461
What is meant by “the deposit”? That which is committed to you, not that which is invented by you. That which you have received, not that which you have devised. A thing not of wit but of learning; not of private assumption but of public tradition; a thing brought to you, not brought forth by you; wherein you must not be an author but a keeper; not a leader but a follower. Keep the deposit. ...
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Nicetas of Remesiana

AD 414
Make strong in your hearts, my brothers, this faith in the Trinity, believing in one God the Father Almighty and in his Son, Jesus Christ our Lord, and in the Holy Spirit, the true light and sanctifier of souls, who is the pledge of our inheritance, who will lead us, if we will but follow, into all truth and will make us one with the citizens of heaven. This rule of faith the apostles received from the Lord…. May this faith remain in you. O beloved, “keep that which is committed to your trust, avoiding profane novelties of words and oppositions of knowledge falsely so called.” ...

Tertullian of Carthage

AD 220
Nothing that was proclaimed before many witnesses could be kept secret. Nor can they [the Gnostic heretics] interpret as evidence of some hidden gospel Paul’s desire that Timothy should entrust “these things to faithful men, fit to teach others.” “These things” meant the things of which he was then writing. To refer to things hidden in their minds he would have said “those,” as of something absent, not “these.” ...
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Tertullian of Carthage

AD 220
The same madness, in their allowing indeed that the apostles were ignorant of nothing, and preached not any (doctrines) which contradicted one another, but at the same time insisting that they did not reveal all to all men, for that they proclaimed some openly and to all the world, whilst they disclosed others (only) in secret and to a few, because Paul addressed even this expression to Timothy: "O Timothy, guard that which is entrusted to thee; " ...
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Vincent of Lérins

AD 445
What does “avoiding” mean? “If anyone comes to you and does not bring this doctrine.” Of course, this means the catholic and universal doctrine, which remains one and the same through all successive ages in the uncorrupted tradition of truth and which will remain so without end for ever and ever.
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Vincent of Lérins

AD 445
“Avoiding,” he says, “profane novelties of words.” Are there really people who can listen to such adjurations and then remain in such hardened and shameless stubbornness, such stony impudence, such adamant consistency, as not to yield to the mighty weight of these divine words and to weaken under such a load, as not to be shattered by these hammer strokes, as not to be crushed by such powerful thunderbolts? “Avoiding,” he says, “profane novelties of words.” He did not say “antiquities” or “the old traditions.” No, he clearly shows the positive implications of this negative statement: Novelty is to be avoided, hence, antiquity has to be respected; novelty is profane, hence, the old tradition is sacred. ...

Knowing this first, that no prophecy of the scripture is of any private interpretation. - 2 Peter 1:20

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