1 Thessalonians 5:23

And the very God of peace sanctify you wholly; and I pray God your whole spirit and soul and body be preserved blameless unto the coming of our Lord Jesus Christ.
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Ambrose of Milan

AD 397
On this subject the Lord says, “When you come into the land to which I bring you and when you eat of the food of the land, you shall present an offering to the Lord. When you separate the firstfruits of your barn floors, you shall also give the firstfruits of your dough to the Lord.” We are a composite of diverse elements mixed together, cold with hot, and moist with dry. This mixture is the source of many pleasures and manifold delights of the flesh. But these are not the firstfruits of this body of ours. Since we are composed of soul and body and spirit, the first place is held by that mixture in which the apostle desires that we find sanctification. “And may the God of peace himself sanctify you completely, and may your spirit and soul and body be preserved sound, blameless at the coming of our Lord Jesus Christ.” .

George Leo Haydock

AD 1849
Spirit, and soul. The former marks the understanding, the latter the will: hence these two terms give the two principal faculties of the soul. (Bible de Vence)

Gregory of Nyssa

AD 394
This, therefore, is perfection in the Christian life in my judgment, namely, the participation of one’s soul and speech and activities in all of the names by which Christ is signified, so that the perfect holiness, according to the eulogy of Paul, is taken upon oneself in “the whole body and soul and spirit,” continuously safeguarded against being mixed with evil. .

Irenaeus of Lyons

AD 202
For he will not possess in that case the likeness and appearance of angels, but of those souls in whom also he receives shape; just as water when poured into a vessel takes the form of that vessel, and if on any occasion it happens to congeal in it, it will acquire the form of the vessel in which it has thus been frozen, since souls themselves possess the figure. ); and may your spirit, and soul, and body be preserved whole without complaint to the coming of the Lord Jesus Christ."

John Chrysostom

AD 407
Observe the affection of the Teacher. After the admonition he adds a prayer; not only that, but even introduces it in his letter. For we need both counsel and prayer. For this reason we also first giving you counsel, then offer prayers for you. And this the Initiated know. But Paul indeed did this with good reason, having great confidence towards God, whereas we are confounded with shame, and have no freedom of speech. But because we were appointed to this we do it, being unworthy even to stand in His presence, and to hold the place of the lowest disciples. But because grace works even through the unworthy, not for our own sakes but for theirs who are about to be benefited, we contribute our parts. Sanctify you wholly, he says, and may your spirit and soul and body be preserved entire, without blame at the coming of our Lord Jesus Christ. What does he here call the spirit? The gift of grace. For if we depart hence having our lamps bright, we shall enter into the bridechamber. But if...

Methodius of Olympus

AD 311
Hence it is necessary that the perfect man offer up all, both the things of the soul and those of the flesh, so that he may be complete and not lacking. Therefore also God commands Abraham,

Tertullian of Carthage

AD 220
Interpret it as meaning anything rather than the substance of the flesh, (tell me) how is it that the apostle has given certain distinct names to all (our faculties), and has comprised them all in one prayer for their safety, desiring that our "spirit and soul and body may be preserved blameless unto the coming of our Lord and Saviour (Jesus) Christ? ". "And as if this were not plain enough, it goes on to say: "And may your whole body, and soul, and spirit be preserved blameless unto the coming of the Lord.". Also present themselves to the rising bodies, and will recognise their several places. But nothing can rise except flesh and spirit sole and pure.

Knowing this first, that no prophecy of the scripture is of any private interpretation - 2 Peter 1:20

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